Neutral Re(I) Complex Platform for Live Intracellular Imaging

Luminescent metal complexes are a valuable platform for the generation of cell imaging agents. However, many cationic, factor that can dominate intracellular accumulation to specific organelles. Neutral Re(I) offer more attractive development bioconjugated agents, where charge cannot influence their distribution. Herein, we report synthesis neutral complex (ReAlkyne), which was used as four carbohydrate-conjugated agents via Cu(I)-catalyzed azide–alkyne cycloaddition. A comprehensive evaluation physical and optical properties each is provided, together with determination utility live in H9c2 cardiomyoblasts. Unlike cationic counterparts, localize within mitochondria, these have localized endosomal/lysosomal network, result consistent examples dinuclear carbohydrate-appended been reported. This further demonstrates platforms viable